INTERMEDIATE FILAMENTS ASSOCIATE WITH AGGRESOME-LIKE STRUCTURES IN PROTEOSTRESSED C. ELEGANS NEURONS AND INFLUENCE LARGE VESICLE EXTRUSIONS AS EXOPHERS

Abstract Toxic protein aggregates can spread among neurons to promote human neurodegenerative disease pathology.We found that in C.elegans touch neurons intermediate filament proteins IFD-1 and IFD-2 associate with aggresome-like organelles and are required cell-autonomously for efficient production of neuronal exophers, giant vesicles that can car

The Sodas good performance of a set of computer systems based on agents depends on the coherence degree and coordination between their activities.The study of coordination problem is an important topic for designers and researchers in the multi-agents systems field.There are several coordination mechanisms in the current literature, being the aucti

Highway guardrail is a kind of important road traffic safety facility.When a vehicle is travelling on a highway, it can lose control because of accident.The guardrail can prevent the vehicle from rushing directly out of the road, so as to reduce the injury to the driver in the vehicle.Therefore, the guiding performance, anti-collision performance a

Gorontalo is the biggest city and the forerunner of the present Gorontalo Province.Gorontalo has been existing since traditional era, Islamic kingdoms, colonial, and up to the present.During the traditional and kingdom era, Gorontalo was the small kingdom included in Ternate area.In fact, it Radius witnessed the changes of power during colonial era

Background and Aim: Amoxicillin antibiotic is one of the antibiotics which is used in medicine and veterinary medicine to treat bacterial infectious Panel mount diseases.In this study, a special electrochemical cell design was used as it could integrate the process units and the operation units to reduce COD and amoxicillin antibiotic residues from